Branched PLGA derivatives with tailored drug delivery properties
نویسندگان
چکیده
منابع مشابه
Mathematical Modeling and Simulation of Intravascular Drug Delivery from Drug-Eluting Stents with Biodegradable PLGA Coating
Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) polymers are often used in the current DES coatings, which stay permanently in the patients. While...
متن کاملModeling and analysis of drug-eluting stents with biodegradable PLGA coating: consequences on intravascular drug delivery.
Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent...
متن کاملPEGylated-PLGA microparticles containing VEGF for long term drug delivery.
The potential of poly(lactic-co-glycolic) acid (PLGA) microparticles as carriers for vascular endothelial growth factor (VEGF) has been demonstrated in a previous study by our group, where we found improved angiogenesis and heart remodeling in a rat myocardial infarction model (Formiga et al., 2010). However, the observed accumulation of macrophages around the injection site suggested that the ...
متن کاملPLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery.
Current approaches to encapsulate and deliver therapeutic compounds have focused on developing liposomal and biodegradable polymeric nanoparticles (NPs), resulting in clinically approved therapeutics such as Doxil/Caelyx and Genexol-PM, respectively. Our group recently reported the development of biodegradable core-shell NP systems that combined the beneficial properties of liposomal and polyme...
متن کاملTetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system
PURPOSE Nanoparticles (NPs) that target bone tissue were developed using poly(lactic-co-glycolic acid) (PLGA) copolymers and tetracycline (TC)-based bone-targeting moieties. These NPs are expected to enable the transport of drugs, such as simvastatin (SIM), for the treatment of osteoporosis. METHODS The molecular structures of TC-PLGA were validated by (1)H-NMR, and the SIM-loaded NPs were pr...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2019
ISSN: 1846-9558
DOI: 10.2478/acph-2020-0011